This is a charade - where two or more words are joined together to form the answer. Look for words that can be combined.
Split this into two parts: 'Home defeat' gives you the first part (a short word meaning at home), and 'means' is your joining indicator. The second part comes from a word meaning defeat or overthrow.
Answer: INREVERSE | This is a charade of IN (home/at home) + REVERSE (defeat/overthrow). 'Means' indicates the two parts should be joined together.