This is a charade - multiple separate components are placed together in sequence to build the final answer.
Look for: a cricket abbreviation for 'maiden', a word meaning 'not well', an abbreviation for 'holy person', and the word 'one' itself. These four parts combine in order to spell out the answer.
Answer: MILLSTONE | M (maiden in cricket) + ILL (not well) + ST (saint, holy person) + ONE = MILLSTONE (unwanted burden)