This uses deletion combined with charade - deletion involves removing letters from a word as indicated, then combining the result with another word or abbreviation.
Look for a word meaning 'lady' and remove its 'heart' (middle letters), then add 'on' or 'about' after it. The result should give you a type of harp.
Answer: LYRE | Take 'lady' and remove the middle letters (AD) to get LY, then add RE (meaning 'on' or 'about') to make LYRE, which is a type of harp.