This is a reversal clue - look for indicators like 'back', 'returned', 'up' (in down clues), or 'west' (in across clues)
Join the wordplay parts together in sequence
Answer: RELEARN | Definition: 'Again pick up' | Wordplay: RE=about, concerning=”on”; plus “end” letter of [miscalculatio]-N after LEAR=”Shakespearean character”